Adenosine A3 receptors regulate heart rate, motor activity and body temperature
نویسندگان
چکیده
منابع مشابه
A1 adenosine receptors potently regulate heart rate in mammalian embryos.
A1adenosine receptors (A1ARs) have been recently shown to be expressed in rodent embryonic hearts at very early stages of development. To determine the functional significance of fetal cardiac A1AR expression during embryogenesis, murine fetal heart preparations were studied between postconceptual days 9 and 12. Dose-response curves generated using a variety of adenosine agonists revealed that ...
متن کاملAdenosine receptors, heart rate, and cardioprotection.
See article by Fabritz et al. [1] (pages 500-508) in this issue. In this issue of Cardiovascular Research, a paper by Fabritz et al. [1] investigates the effects of controlled overexpression of the A3 adenosine receptor (A3AR) in the mouse heart. Their findings will feed further the current debate on the use of adenosine receptors (AR) as targets for gene therapy aimed at protecting the myocard...
متن کاملA3 adenosine receptors regulate Cl-channels of nonpigmented ciliary epithelial cells.
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in isotonic suspensions with the cationic ionophore gramicidin present. The A3-selective agonist N 6-(3-iodobenzyl)-adenosine-...
متن کاملA3 adenosine receptors regulate Cl2 channels of nonpigmented ciliary epithelial cells
CLAIRE H. MITCHELL,1 KIM PETERSON-YANTORNO,1 DAVID A. CARRÉ,1 ALICE M. MCGLINN,2 MIGUEL COCA-PRADOS,3 RICHARD A. STONE,2 AND MORTIMER M. CIVAN1,4 Departments of 1Physiology, 2Ophthalmology, and 4Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6085; and 3Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connec...
متن کاملThe role of adenosine A3 receptors in cytotoxicity of the breast cancer cell lines
The nucleoside adenosine is present within cells and body fluids of all living organisms and its production, both intra- and extracellularly, is tightly coupled to energy consumption resulting in increased level of extracellular adenosine. The physiological effects of adenosine are mediated through four pharmacologically and biochemically distinct adenosine receptors (AR), i.e. A1, A2A, A2B and...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2010
ISSN: 1748-1708,1748-1716
DOI: 10.1111/j.1748-1716.2010.02091.x